![]() It is well known that agents targeting IL-13, IL-4 (e.g., lebrikizumab, tralokinumab, and dupilumab) and JAK inhibitors (e.g., abrocitinib, upadacitinib, and baricitinib) are efficacious in treating atopic dermatitis. Inflammation is characterized by symptoms such as pain, heat, itching, redness, and swelling.Īt present, the marketed drugs aim to reduce inflammation through regulating and/or suppressing immune responses and then improve function of skin, thus ameliorate clinical symptoms and signs with pruritus ( Huang et al., 2022). Meanwhile, it is a main feature of skin disorders ( Nicolaou, 2013). ![]() Inflammation is a complex process which mediates skin healing and repairs after injury. However, excessive inflammation can lead to tissue lesion. Inflammation is an approach to protect cells and to regulate the stimulus including allergens, mechanical stress, irritants, toxins, and pathogens. ![]() The inflammation of skin is also a main sign of endocrine disorder and chronic autoimmune inflammatory diseases, such as lupus erythematosus, atopic dermatitis, psoriasis, atopic dermatitis, and excessive pigmentation ( Yang et al., 2022). These diseases may induce inflammation-mediated skin diseases. Excessive or insufficient secretion of hormones will cause many diseases. Hormones secreted by adrenal gland play an important role in maintaining physiological function of body. Immune dysregulations in allergic reactions, infections, and internal disorders usually cause cutaneous inflammation. And both sides mentioned above play a key role in development and therapy of cutaneous diseases ( Rashtak and Pittelkow, 2008). The unfavorable appearance resulting from cutaneous inflammation affects the mental condition of the patient. The skin is a well-known reflection of internal pathologic conditions. The functions of the skin are important for the healthy and aesthetic conditions ( Michalak, 2022). Skin is a diverse and extensive organ of the human body. And the published papers indicated that natural products might be a potential source for treating skin diseases. This article summarized the effects of natural products on skin inflammation caused by abnormal hormone secreted by adrenal gland. We systematically searched the relevant articles from databases, including PubMed, Embase, and Cochrane library databases, to review the effects of natural products on skin disorders. The natural products may also promote skin wound healing by inhibiting the production of matrix metalloproteinase-9. According to the previous evidences, natural products have the potential properties for attenuating skin disorders and improving dermatologic symptoms by inhibiting inflammation through MAPK or PI3K/AKT-dependent NF-κB pathways. Endocrinologic disorders often induce cutaneous abnormalities. It provides protection and acts as a barrier against external damage factors like infectious organisms, chemicals, and allergens. Hypersecretion or hyposecretion by the adrenal gland will cause a complex cascade of hormone effects and lead to diseases, including Addison’s disease, Cushing’s syndrome, and congenital adrenal cortical hyperplasia. These hormones play an important role in regulating blood pressure, metabolism, and homeostasis of glucose or electrolytes. The medulla of adrenal gland secrets catecholamines. The cortex of adrenal gland produces glucocorticoid, mineralocorticoid, and androgen. ![]()
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